Detailed view for PF3D7_1431800

Basic information

TDR Targets ID: 2628
Plasmodium falciparum, apyrase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4882 | Length (AA): 874 | MW (Da): 105033 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01150   GDA1/CD39 (nucleoside phosphatase) family

Gene Ontology

Mouse over links to read term descriptions.
GO:0017110   nucleoside-diphosphatase activity  
GO:0008150   biological_process  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016787   hydrolase activity  

Metabolic Pathways

Purine metabolism (KEGG)
Pyrimidine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
79 285 3aap (A) 47 230 38.00 0 1 0.467742 0.81
470 650 4u5a (A) 48 239 22.00 0.19 0.18 0.452394 -0.84
75 457 4cd1 (A) 39 433 20.00 0 1 0.410615 0.34
79 285 3aap (A) 47 230 38.00 0 0.71 0.445642 0.74
522 703 4u5a (C) 47 239 18.00 0.14 0.04 0.353038 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, early trophozoite, late ring, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, Oocyst, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, Female Gametocyte, Male Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_133039)

Species Accession Gene Product
Arabidopsis thaliana AT1G14240   probable apyrase 3
Arabidopsis thaliana AT1G14250   probable apyrase 5
Arabidopsis thaliana AT1G14230   probable apyrase 4
Echinococcus granulosus EgrG_000828300   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_001128400   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_000828350   ectonucleoside triphosphate diphosphohydrolase
Echinococcus multilocularis EmuJ_000828300   ectonucleoside triphosphate diphosphohydrolase
Homo sapiens ENSG00000138185   ectonucleoside triphosphate diphosphohydrolase 1
Mus musculus ENSMUSG00000048120   ectonucleoside triphosphate diphosphohydrolase 1
Oryza sativa 4345665   Os08g0436100
Plasmodium falciparum PF3D7_1431800   apyrase, putative
Schistosoma japonicum Sjp_0000930   ko:K01510 apyrase [EC3.6.1.5], putative
Schistosoma mansoni Smp_042020.1   ATP-diphosphohydrolase 1
Schmidtea mediterranea mk4.023807.00   Guanosine-diphosphatase, putative
Schmidtea mediterranea mk4.001642.03   ATP-diphosphohydrolase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ectonucleoside triphosphate diphosphohydrolase 1 Compounds References
Bos taurus Ectonucleoside triphosphate diphosphohydrolase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.038 0.8211 1
0.038 0.8211 1
0.0363 1 1
0.0214 0.5563 0.5
0.0307 1 1
0.0267 1 1
0.0352 0.3416 0.7069
0.0352 0.3416 0.7069
0.0277 0.9134 1
0.042 0.2508 1
0.0027 0.2563 0.9058
0.0402 0.3704 1
0.0205 1 0.5
0.0358 0.3157 1
0.0172 0.2997 1
0.0294103 1 1
0.0368 0.2567 1
0.0287 1 1
0.0037 0.2556 0.5839
0.0323 1 1
0.0384 0.5499 1
0.0333 1 1
0.0409 0.4068 1

Assayability

Assay information

  • Assay for Apyrase AMP (3.6.1.5 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

9 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1431800 (Plasmodium falciparum), apyrase, putative
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